Khan made his debut in 1992 with Parampara. He had his major success with the 1994 films Main Khiladi Tu Anari and Yeh Dillagi. After starring in several box office failures throughout the 1990s, he gained acclaim and rose into prominence with his performance in Dil Chahta Hai (2001), and went on to turn his career professionally after that. He was praised for his performance in Nikhil Advani's hit Kal Ho Naa Ho (2003), which won him the Filmfare Best Supporting Actor Award, and won the coveted National Film Award for Best Actor for his performance in another hit Hum Tum (2004). He then had commercial success with films like Salaam Namaste (2005) and Ta Ra Rum Pum (2007), and starred in numerous critically acclaimed projects such as Parineeta (2005) and Omkara (2006). These successes put him among the most successful actors in the industry.
Saif Ali Khan was born into the family of the Nawabs of Pataudi. His grandfather, Iftikhar Ali Khan Pataudi, was the Nawab of Pataudi as well as an accomplished cricketer who played for England and then for India as the captain of the team. His paternal grandmother was Sajida Sultan, Begum of Bhopal and his great-uncle was Pakistani general Nawabzada Sher Ali Khan Pataudi.
His father, Mansoor Ali Khan Pataudi, like Nawab of Pataudi Sr., was not only the Nawab of Pataudi but also a former captain of the Indian cricket team. His mother, Sharmila Tagore, is a Bengali Indian film actress, head of the Indian film censorship board and a relative of the Nobel laureate - Rabindranath Tagore. Saif is also distantly related to the late Nafisa Joseph through his mother. Khan has two sisters: Soha Ali Khan and Saba Ali Khan.
Initially Saif studied at the Lawrence School Sanawar but later attended Lockers Park Prep School. Later, he followed in his father's footsteps by attending Winchester College, a famous independent school for boys in UK.
Khan married actress Amrita Singh in October 1991. The marriage made news as Amrita was twelve years older than him. After thirteen years of marriage and two children, a daughter named Sara and a son named Ibrahim, the couple divorced in 2004. His children live with their mother.
In 1998, Khan was charged with poaching two blackbucks in Kankani during the filming of Hum Saath Saath Hain along with co-stars Salman Khan, Tabu, Sonali Bendre and Neelam. The charges were dropped soon after and Khan was acquitted.
The tabloids have often linked him with many other Bollywood stars, but he has denied all these rumours. After he divorced his wife, Khan began dating Rosa Catalano, whom he broke up with in 2007. Khan is currently dating actress Kareena Kapoor. At the grand finale of the Lakme Fashion Week, he declared that they were indeed a couple and were seeing each other.
On February 18, 2007, Khan was hospitalized at Lilavati Hospital, Mumbai due to experiencing chest pain while rehearsing for his performance at the Stardust Awards, to be held that night. Many film personalities came to see the actor in hospital. After hospitalisation, he stated he would quit smoking.
